seperation of the keratin and epidermal skin surface in scales or sheets. Drugs relevant to dermatology Urticaria are wheals in the skin resulting from the release of histamine or other vasoactive substances. Inflammation of the skin in the body folds. A bulla is a circumscribed elevation of skin of 0.5 cm or more in diameter containing a liquid. The distinction between vesicle and bulla is arbitrary and depends only on size (vesicles are less than 0.5 cm). A plug of keratin and sebum in a dilated pilosebaceous orifice Chronic inflammatory tissue composed of macrophages, fibroblasts, and granulation tissue. Microscopic Pathology finding. Disorder of the axillary apocrine glands manifested by pruritic dome-shaped follicular papules. linear gap or slit in the skin surface. dried of exudate, secretion, or hemorrhage an elevated progressive scar formation without regression. Any objective evidence of disease. A vesicle or bulla formed by cleavage of the dermal-epidermal interface and with the roof of the bulla composed of the epidermis. Example: bullous pemphigoid commonly found in bedridden patients left in a fixed position for long periods of time. Increase of terminal hairs in androgen dependent areas such as the groin, axilla, nipple, and face. Other Structural elements deep bacterial skin infections. Hypertrichosis is an increase in non-androgen dependent hair. Excess sweating from the eccrine sweat glands. hyperplasia of the stratum corneum due to chronic, repetitive physical pressure. A bulla caused by separation of tissue components of the dermis with collection of serous fluid. Example: dystrophic epidermolysis bullosa An intraepidermal multilocular vesicle or blister formed by separation of epidermal cells by edema. Example: Contact Dermatitis A bulla formed by exudate beneath the stratum corneum, and above the stratum spinosum. Example: bullous impetigo Skin infection multiple epidermoid cysts, polyposis of the colon, and osteomas. Death of tissue, associated with loss of blood supply. herpes simplex virus spreading in areas of a pre-existing dermatologic condition, most commonly atopic dermatitis. Occurring in early childhood, lesions can be solitary or multiple. The red-brown to yellow papules are most common on the face or upper trunk. A localized pyogenic infection originating in a hair follicle. inflammation of the pilosebaceous follicle. abnormal condition of the body or mind that causes discomfort, dysfunction, or distress cytologic dysplasia seen on histology deep skin infections A keratosis which is taller than it is broad. Structure at the microscopic level A necrotizing infection of skin and subcutaneous tissue. closed cavity or sac (normal or abnormal) with an epithelial, endothelial or membranous lining and containing fluid or semisolid material. burning pain in the extremities. 23 june 2006 beapen This class is for living endurants. It is important to differentiate living and non-living as different rules apply to both. pyogenic infection of the skin. Hemorrhage in skin or mucous membrane more than 2 mm in diameter. a bacterial cellulitis caused by Streptococcus spp. loss of substance of skin produced by scratching. beapen A symptom is, by its nature, subjective. It is something only the patient can know. This class is for non-living endurants. It is important to differentiate living and non-living as different rules apply to both. A localized collection of blood. cysts containing keratin. proliferation of secretary apocrine or eccrine glands. Develop secondary to solar exposure. A tunnel in the skin that houses a metazoal parasite, particularly the acarus of scabies. Hemangiomas are benign developmental vascular malformations. A physical sign loss of the epidermis which heals without scarring. A blister formed within the epidermis by pathologic change in epidermal cells or cellular cohesion. Example: miliaria crystallina Hair loss tumor composed of vascular channels surrounded by proliferating glomus cells. A generalized redness of the skin. A diminution of a tissue. Clears within 1-6 weeks Lasts for more than 6 weeks. Bell Eapen (GulfDoctor.net) A domain ontology for dermatology