GulfDoctor.net - A site for dermatologists & bioinformaticians by Bell Raj Eapen

PUBLICATIONS
[ Pubmed Citations | Google Scholar Citations]

(1.) Eapen BR. A new insight into the pathogenesis of Reiter's syndrome using bioinformatics tools.International Journal of Dermatology March-2003. 42 (3); 242-243. [Pubmed Citation]

Blast search of HLA B27 against prokaryotes genomic database did not show any significant similarity to bacteria implicated in Reiter's. However a contiguous gene LY95 on 6p21-31, a surface receptor involved in natural killer cell triggering showed homology with samonella enteritica serovar typhi. Is Reiter's syndrome a result of bacterial molecular mimicry with LY95? Click on the links for more information.
[Abstract]

(2) Eapen BR. Molecular biology of Botulinum Toxin Serotype A (BoNT/A): A Cosmetic perspective. Journal of cosmetic dermatology (2008). 7 ; 221-225 [Pubmed]

(3) Eapen BR. ONTODerm - A domain ontology for dermatology. Dermatology Online Journal 14 (6): 16 [Full Text] [Pubmed] [Project Home Page]

(4.) Eapen BR. Photosensitivity in Smith-Lemli-Opitz syndrome: A flux balance analysis of altered metabolism. Bioinformation 2 (2):78-82 (2007) [Full Text] [Pubmed] [Details]

(5) Eapen BR. Schwann cell invasion by M. leprae: the probable trojan horse. Lepr Rev. 2008 Sep;79(3):335-7. [Full Text | Pubmed | Journal Website]

(6) Eapen BR. Myeloid differentiation factor 88 (MyD88): An innocent bystander or an active player - Pathway level analysis of expression data in psoriasis. Journal of Investigative Dermatology (Suppl). 2008; 128: S132 [Abstract - #787 [pdf]]

(7) Eapen BR. Malignancy in dermatomyositis: A Bayesian Belief Network approach. Indian J Dermatol Venereol Leprol 2007;73:445-5 [Full Text] [Details]

(8) Bell Raj Eapen. M. Leprae genome revisited using the latest bioinformatics tools. (Accepted for publication in Gulf Journal Of Dermatology & Venereology in April 2002 issue)
M.Leprae genome was analysed and compared to M.tuberculosis genome to seek explanations for the unique features of M.Leprae. The protein implicated in M.leprae's nerve predilection (Alpha 2 Laminin) is shared by many mycobacteria [Click Here]. No human nerve protein homologues were found [Click Here]. 18KDa cytoplasmic antigen of M.Leprae showed little similarity to other mycobacterial proteins [Click Here]. A possible 'horizontal gene transfer' was also demonstrated [Click Here].

(9)Sandra A, Eapen BR, Shenoi SD. Effect of thickness of sunscreen on SPF. British Journal of Dermatology (Suppl). 2000; 143 (57): 24 [Citation]

(10) Eapen BR. Structural analysis of Staphylococcal enterotoxin G (SEG) and its inactive mutant (SEGL29P) using the bioinformatics tools. Biomedicine. 2002; 22: 89-93. [Citation]
Bacterial superantigens are implicated in various inflammatory & non-inflammatory diseases. The conformational change probably responsible for loss of function following a point mutation in staphylococcal enterotoxin G is predicted using protein structure prediction software.

(11) Eapen BR. Vit1 gene in Vitiligo - Letter to Ed. Indian J Dermatol Venerol Leprol. 2004;70:184.
VIT1, the recently discovered gene in vitiligo codes for a protein which has a ubiquitin like N-recognin domain. This can explain many of the characteristics of vitiligo like its heritability, aggravation with stress, non-inflammatory melanocytic apoptosis and response to steroids. Valuable clues as to probable treatment options can also be obtained. [Full Text] [Pubmed]

(12) Eapen BR. Neural network algorithm to predict the severity of Epidermolysis Bullosa Simplex. Indian J Dermatol Venerol Leprol. 2005;71:106-8. [Full Text] [Pubmed]

(13) Bell Raj Eapen, Murali Srinivasan, Geetanjali Bhas. Antibiotic sensitivity profile of common bacterial pathogens in Dubai – A study of 107 cases. MEJFM 2005; 3(4): 28 - 32 [Full Text]

(14) Bell Raj Eapen. Bioinformatics - A Clinician's perspective. Bioinformatics - India Apr-jun(2003). 1 (1); 17-18. [Abstract]

(15) Bell Raj Eapen, Shrutakirthi D Shenoi, Sandra A. Patch Testing with Shoe series in suspected cases of footwear dermatitis. Indian J Dermatol 2001; 46(3): 146-148 [Abstract]

(16). Bell Raj Eapen, T Salim, S D Shenoi. Clinical Presentation and treatment outcome in Systemic Lupus Erythematosus. (Vol 47 No 3 July - September 2002, Indian Journal of Dermatology). [Abstract]

(17) Bell Raj Eapen, Shobana S, Anandan S. Waist dermatoses in Indian women wearing saree Indian J Dermatol Venerol Leprol. 2003;69:88-89. [FULL TEXT][Pubmed]

(18) R Sudha, SB Hussain, E Bellraj et al. Clinico Pathological study of Exfoliative Dermatitis. Indian J Dermatol Venerol Leprol. 2003;69:30-31.

(19) Murali Srinivasan, Bell Raj Eapen, Geetanjali Bhas, Cyril Kumar T. Efficacy of Chlorhexidine Mouthwash as an Oral Antiseptic - An Invivo Study on 20 Patients. MEJFM 2005; 3(4): 28 - 32 [Full Text]

(20) Eapen BR. Data sharing using internet: A suggestion - Letter to Ed. Indian J Dermatol Venerol Leprol. 2003;69:194.[FULL TEXT][Pubmed]

(21) Eapen BR. EndNote 7.0. Indian J Dermatol Venerol Leprol. 2006;72(2):165-6. [Full Text] [Pubmed]

(22) Eapen BR. Blog your clinical photos. Letter to Ed. Indian J Dermatol Venerol Leprol. 2006;72(3):231. [Full Text] [Pubmed]

(23) Bell Raj Eapen. Informatics in Clinical Practice Monitoring and Strategic Planning. MEJFM 2006; 4(5): 72 - 76 [Full Text]

(24) Eapen BR. Collaborative writing: Tools and tips. Indian J Dermatol Venereol Leprol 2007;73:439-41 [Full Text] [Pubmed]

(25) Eapen BR. Vitiligo, psoriasis and imiquimod: Fitting all into the same pathway. Indian J Dermatol Venereol Leprol. 2008 Mar-Apr;74(2):169. [Full Text] [Pubmed] [Author's reply]

(26) Eapen BR. ErbB2: Nonimmune genetic key to leprosy. Indian J Dermatol Venereol Leprol. 2008 May-Jun;74(3):272-73. [Full Text] [Pubmed]

(27) Eapen BR. DermaMan: Scoring dermatology in your palm. Indian J Dermatol Venereol Leprol. 2008 Jul-Aug;74(4):424-6. [Full Text | Pubmed | Details]

On the Web

(28) Melanocyte Culture and Transfer – For Vitiligo & Beyond. GulfMD.com [FULL TEXT]

(29) Dermatology Questions & Answers. GulfMD.com [FULL TEXT]

[ Pubmed Citations | Google Scholar Citations]